Anytime we add extra energy, assessment, judgment, evaluation, celebrity, grandeur, meaning, impact, emotion, thought, or resistance to something. We can have a fly land on us and simply feel the legs or we can run around screaming that we have been infected by a deadly disease I KNOW I’M GOING TO DIE NOW. The latter is a form of significance. Somethings we add significance to on purpose. Weddings, graduations, funerals etc. which is good it increases the way they are created and the impact they have on us. So significance isn’t bad, it is simply something extra. The key is to be conscious of where we add significance and to only do it when and where we declare it serves our values.